Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism

@article{BonillaRamrez2011AcuteAC,
  title={Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism},
  author={Leonardo Bonilla-Ram{\'i}rez and Marlene Jimenez-Del-Rio and Carlos Velez-Pardo},
  journal={BioMetals},
  year={2011},
  volume={24},
  pages={1045-1057}
}
The biometals iron (Fe), manganese (Mn) and copper (Cu) have been associated to Parkinson’s disease (PD) and Parkinsonism. In this work, we report for the first time that acute (15 mM for up to 5 days) or chronic (0.5 mM for up to 15 days) Fe, Mn and Cu exposure significantly reduced life span and locomotor activity (i.e. climbing capabilities) in Drosophila melanogaster. It is shown that the concentration of those biometals dramatically increase in Drosophila’s brain acutely or chronically fed… CONTINUE READING
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