Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats.

@article{Vajner2006AcuteAC,
  title={Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats.},
  author={Luděk Vajner and Richard Vyt{\'a}{\vs}ek and Vera Lachmanov{\'a} and Jiř{\'i} Uhl{\'i}k and V{\'a}clava Konr{\'a}dov{\'a} and Jana Novotn{\'a} and V{\'a}clav Hampl and Jan Herget},
  journal={International journal of experimental pathology},
  year={2006},
  volume={87 5},
  pages={383-91}
}
Chronic hypoxia results in pulmonary hypertension due to vasoconstriction and structural remodelling of peripheral lung blood vessels. We hypothesize that vascular remodelling is initiated in the walls of prealveolar pulmonary arteries by collagenolytic metalloproteinases (MMP) released from activated mast cells. Distribution of mast cells and their… CONTINUE READING