Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors.

@article{Klein2008AcuteAC,
  title={Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors.},
  author={Gad E Klein and Aaron Juni and Caroline A Arout and Amanda R. Waxman and Charles E. Inturrisi and Benjamin Kest},
  journal={European journal of pharmacology},
  year={2008},
  volume={586 1-3},
  pages={179-88}
}
Opioid and excitatory amino acid receptors contribute to morphine dependence, but there are no studies of their role in heroin dependence. Thus, mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists: 7-benzylidenenaltrexone (BNTX), naltriben (NTB), nor-binaltorphimine (nor-BNI; delta1, delta2, and kappa opioid receptors, respectively), MK-801, or LY293558 (NMDA and AMPA excitatory amino acid receptors, respectively… CONTINUE READING

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Thus , mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists : 7-benzylidenenaltrexone ( BNTX ) , naltriben ( NTB ) , nor - binaltorphimine ( nor - BNI ; delta1 , delta2 , and kappa opioid receptors , respectively ) , MK-801 , or LY293558 ( NMDA and AMPA excitatory amino acid receptors , respectively ) .
Thus , mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists : 7-benzylidenenaltrexone ( BNTX ) , naltriben ( NTB ) , nor - binaltorphimine ( nor - BNI ; delta1 , delta2 , and kappa opioid receptors , respectively ) , MK-801 , or LY293558 ( NMDA and AMPA excitatory amino acid receptors , respectively ) .
Thus , mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists : 7-benzylidenenaltrexone ( BNTX ) , naltriben ( NTB ) , nor - binaltorphimine ( nor - BNI ; delta1 , delta2 , and kappa opioid receptors , respectively ) , MK-801 , or LY293558 ( NMDA and AMPA excitatory amino acid receptors , respectively ) .
Thus , mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists : 7-benzylidenenaltrexone ( BNTX ) , naltriben ( NTB ) , nor - binaltorphimine ( nor - BNI ; delta1 , delta2 , and kappa opioid receptors , respectively ) , MK-801 , or LY293558 ( NMDA and AMPA excitatory amino acid receptors , respectively ) .
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