Acute and chronic ethanol tolerance: operant behaviour in naive and ethanol tolerant rats

@article{Hiltunen1992AcuteAC,
  title={Acute and chronic ethanol tolerance: operant behaviour in naive and ethanol tolerant rats},
  author={Arto J Hiltunen and Torbj{\"o}rn U. C. J{\"a}rbe},
  journal={Psychopharmacology},
  year={1992},
  volume={107},
  pages={511-516}
}
The relationship between tolerance to ethanol and acute tolerance to ethanol was examined. One group of rats was given 1.8 g/kg ethanol, and another group was administered 18 ml/kg saline for 26 days after sessions. Animals responded under a fixed ratio ten (FR-10) schedule of food reinforcement. Thereafter, various doses of ethanol (1.3–2.5 g/kg) were examined to assess the influence of the ethanol treatment on the expression of acute tolerance. Acute tolerance was assessed by comparing the… CONTINUE READING

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