Acute and chronic ethanol modulate dopamine D2-subtype receptor responses in ventral tegmental area GABA neurons.

@article{Ludlow2009AcuteAC,
  title={Acute and chronic ethanol modulate dopamine D2-subtype receptor responses in ventral tegmental area GABA neurons.},
  author={Kimberly H Ludlow and Katie D Bradley and David W Allison and Seth R. Taylor and Jordan T Yorgason and David M. Hansen and Christine H Walton and Sterling N Sudweeks and Scott C Steffensen},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 5},
  pages={804-11}
}
BACKGROUND Ventral tegmental area (VTA) gamma-aminobutyric acid (GABA) neurons appear to be critical substrates underlying the acute and chronic effects of ethanol on dopamine (DA) neurotransmission in the mesocorticolimbic system implicated in drug reward. VTA GABA neuron firing rate is reduced by acute ethanol and enhanced by DA via D2 receptor activation. The objective of this study was to evaluate the role of D2 receptors in acute ethanol inhibition of VTA GABA neuron activity, as well as… CONTINUE READING

Similar Papers

Loading similar papers…