Acute and chronic estradiol replacements differentially alter corticosterone and COX-mediated responses to an inflammatory stimulus in female rats.

@article{Kuba2010AcuteAC,
  title={Acute and chronic estradiol replacements differentially alter corticosterone and COX-mediated responses to an inflammatory stimulus in female rats.},
  author={Tzipora Kuba and Deirtra A Hunter and Luyi Zhou and Shirzad Jenab and Vanya Qui{\~n}ones-Jenab},
  journal={Ethnicity & disease},
  year={2010},
  volume={20 1 Suppl 1},
  pages={S1-50-4}
}
INTRODUCTION This study aimed to determine whether the previously reported differential effects of estradiol on inflammation-induced behavioral responses are in part explained through differential activation of the corticosterone-cyclooxygenase (CORT-COX) regulatory pathway. METHODS Prostaglandin E2 (PGE2), COX, and CORT levels were analyzed before and… CONTINUE READING