Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

  title={Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites},
  author={M. A. Blackshear and Roberta L. Friedman and E. sanders-Bush},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • M. A. Blackshear, Roberta L. Friedman, E. sanders-Bush
  • Published 2004
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • SummaryThe administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (Bmax) of 3H-spiroperidol binding sites (5HT2 sites) in frontal cortex, when assayed 48 h after the last dose; the apparent affinity (KD) of 3H-spiroperidol was not changed. The same treatment schedules failed to modify the KD and Bmax values for 3H-5HT binding to the 5HT1 site in the hippocampus. Cyproheptadine, BC-105 and methysergide, but not metergoline… CONTINUE READING
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