Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.

@article{France2006AcuteAC,
  title={Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.},
  author={Charles P France and Robert H Weltman and Wouter Koek and Christopher M Cruź and Lance R McMahon},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 3},
  pages={
          535-41
        }
}
The acute and chronic effects of ramelteon, an MT1/MT2 receptor agonist, were evaluated in rhesus monkeys (Macaca mulatta) to assess discriminative stimulus effects in comparison with traditional benzodiazepine receptor agonists and to assess physical dependence potential. Discriminative effects of ramelteon were compared with midazolam in untreated monkeys and in diazepam-dependent monkeys that discriminated flumazenil. Dependence potential of ramelteon after daily 1-year administration (and… CONTINUE READING

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SHOWING 1-10 OF 27 REFERENCES

A safety, tolerance, and pharmacokinetic study of five single doses of TAK-375 in healthy adults

  • C. Stubbs, A. Karim
  • [Abstract]. Sleep,
  • 2003
Highly Influential
1 Excerpt

Double - blind , placebo - controlled polysomnography and outpatient trial to evaluate the efficacy and safety of ramelteon in adult patients with chronic insomnia [ Abstract ]

  • G. Zammit, T. Roth, M. Erman, S. Sainati, S. Weigand, J. Zhang
  • Brain Research
  • 2005
2 Excerpts

Double-blind, placebo-controlled polysomnography and outpatient trial to evaluate the efficacy and safety of ramelteon in adult patients with chronic insomnia

  • G. Zammit, T. Roth, M. Erman, S. Sainati, S. Weigand, J. Zhang
  • [Abstract]. Sleep,
  • 2005
2 Excerpts

Phase III outpatient trial of ramelteon for the treatment of chronic insomnia in the elderly [Abstract

  • T. Roth, D. Seiden, +4 authors J. Bayuk
  • Journal of the American Geriatric Society,
  • 2005

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