• Corpus ID: 24738714

Acute and chronic effects of flupenthixol on the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys.

@article{Negus1996AcuteAC,
  title={Acute and chronic effects of flupenthixol on the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys.},
  author={S Stevens Negus and Nancy K. Mello and Xavier Lamas and Jack H. Mendelson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 2},
  pages={
          879-90
        }
}
  • S. Negus, N. Mello, +1 author J. Mendelson
  • Published 1 August 1996
  • Psychology, Medicine
  • The Journal of pharmacology and experimental therapeutics
It has been proposed that the relatively nonselective dopamine receptor antagonist flupenthixol may be useful in the treatment of cocaine dependence. Drugs used in the treatment of cocaine dependence are administered chronically; however, most preclinical studies have examined only the acute effects of flupenthixol treatment on the effects of cocaine. Consequently, the purpose of the present study was to compare the effects of acute and chronic treatment with flupenthixol (0.0032-0.032 mg/kg… 
Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys.
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It is suggested that although indatraline may decrease cocaine-taking behavior in rhesus monkeys, it also produces undesirable side effects that may limit its clinical utility in the treatment of cocaine dependence.
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Effects of Flupenthixol and Quadazocine on Self-Administration of Speedball Combinations of Cocaine and Heroin by Rhesus Monkeys
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The findings suggest that medication mixtures designed to target both the stimulant and opioid component of the speedball combination, may be an effective approach to polydrug abuse treatment.
The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats
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Data confirm a role for DA transmission in cocaine reward but suggest that different neural pathways mediate the drug's negative/anxiogenic properties.
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Chronic treatment with D1 receptor partial agonists produced dose-dependent effects on cocaine self-administration that may be relevant to their further evaluation as candidate medications for the treatment of cocaine dependence.
Effects of Indatraline and Buprenorphine on Self-Administration of Speedball Combinations of Cocaine and Heroin by Rhesus Monkeys
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Findings suggest that medication mixtures designed to target both the stimulant and opioid component of the speedball combination may be an effective approach to polydrug abuse treatment.
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  • N. Mello, S. Negus
  • Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1998
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It is suggested that kappa opioid agonists may be a useful approach to the development of new pharmacological treatments for cocaine dependence and undesirable side effects may limit their clinical usefulness.
Effect of flupenthixol on subjective and cardiovascular responses to intravenous cocaine in humans.
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It is indicated that flupenthixol is not a good candidate for treating cocaine abusers and there were few subjective, cardiovascular, or cocaine pharmacokinetic differences between the placebo group and the low dose flup tenthixol group, indicating that theLow dose of flup Tenthixol was well tolerated, but ineffective.
Modulation of cocaine's discriminative stimulus effects by dopamine D1 agonists in rhesus monkeys
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Results indicate that D(1) agonists have cocaine-like discriminative stimulus effects in rhesus monkeys that are consistent with their in vitro efficacies, however, when given in combination with cocaine, D( 1) agonist efficacy does not appear to be a major factor in modifying cocaine's discriminatives stimulus effects.
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