Acute and chronic effects of dexfenfluramine on the porcine coronary artery.

@article{Desta1996AcuteAC,
  title={Acute and chronic effects of dexfenfluramine on the porcine coronary artery.},
  author={Berhanu Desta and David H Schultz and Denis Ravel and N Laudignon and Paul Michel Vanhoutte and Chantal M Boulanger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={279 3},
  pages={1077-85}
}
Experiments were designed to verify whether or not acute or chronic exposure to dexfenfluramine favors the occurrence of coronary vasospasm in vivo or in vitro. Rings of left anterior and left circumflex porcine coronary artery, with and without endothelium, were studied in conventional organ chambers for the measurement of isometric force. The donor pigs were divided into two groups: controls and animals fed for 4 weeks with dexfenfluramine. In each group, one-half of the animals underwent… CONTINUE READING