Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala.

@article{Bosker2001AcuteAC,
  title={Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala.},
  author={Fokko J. Bosker and Thomas I. H. F. Cremers and Minke E. Jongsma and Ben H. C. Westerink and H{\aa}kan V. Wikstr{\"o}m and Johan A. den Boer},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 6},
  pages={1645-53}
}
Microdialysis was used to assess the involvement of postsynaptic 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in the regulation of extracellular 5-HT in the amygdala. Local infusion of the 5-HT(1A) receptor agonist flesinoxan (0.3, 1, 3 microM) for 30 min into the amygdala maximally decreased 5-HT to 50% of basal level. Systemic administration of citalopram (10 micromol/kg) increased 5-HT to 175% of basal level. Local infusion of 1 microM of the 5-HT(1A) receptor antagonist WAY 100.635 into the… CONTINUE READING

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