Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.

@article{Liu1996AcuteAC,
  title={Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.},
  author={M C Liu and Louise M. Dub{\'e} and Jack Lancaster},
  journal={The Journal of allergy and clinical immunology},
  year={1996},
  volume={98 5 Pt 1},
  pages={859-71}
}
BACKGROUND Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid metabolism may mediate bronchoconstriction and inflammatory changes important in the pathophysiology of asthma. Leukotriene inhibition may be effective in asthma management. OBJECTIVE This clinical trial was performed to assess the long-term efficacy and safety of zileuton, an inhibitor of 5-lipoxygenase. METHODS In this multicenter, double-blind, parallel-group, placebo-controlled trial, 600 mg of zileuton… CONTINUE READING

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