Acute and chronic amphetamine treatments differently regulate neuropeptide messenger RNA levels and Fos immunoreactivity in rat striatal neurons.

@article{Jaber1995AcuteAC,
  title={Acute and chronic amphetamine treatments differently regulate neuropeptide messenger RNA levels and Fos immunoreactivity in rat striatal neurons.},
  author={Mohamed Jaber and Martine Cador and Brigitte Dumartin and Elisabeth Normand and Luis Stinus and Bertrand Bloch},
  journal={Neuroscience},
  year={1995},
  volume={65 4},
  pages={1041-50}
}
Repeated administration of amphetamine results in the well known phenomenon of reverse tolerance or sensitization. However, little is known about cellular and molecular mechanisms underlying acute versus chronic response to amphetamine. In this paper, we investigated the effects of acute (1.5 or 5 mg/kg) and chronic (5 mg/kg/day for 14 days) amphetamine treatment on locomotor activity, stereotypy, Fos immunoreactivity and messenger RNA levels of molecules implicated in dopamine transmission in… CONTINUE READING
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