Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

@article{DellaZuana2002AcuteAC,
  title={Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats},
  author={Odile Della-Zuana and Françoise Presse and Christine Ortola and Jacques Duhault and JL. Nahon and Nigel R. Levens},
  journal={International Journal of Obesity},
  year={2002},
  volume={26},
  pages={1289-1295}
}
AIM: Although melanin-concentrating hormone (MCH) is believed to be an important regulator of feeding behavior, both its acute and chronic effects on food intake as well as its interaction with other brain peptides involved in the control of appetite remain unclear. Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats.METHODS AND RESULTS… Expand
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TLDR
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Melanin-concentrating hormone functions in the nervous system: food intake and stress
  • G. Hervieu
  • Biology, Medicine
  • Expert opinion on therapeutic targets
  • 2003
TLDR
The discovery of MCH-R1 antagonists may lead to the development of valuable drugs to treat obesity, anxiety and depressive syndromes, and opens wide avenues to probe additional functions of the peptide, both in the brain and in the peripheral nervous system. Expand
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Results demonstrate that MCH stimulates feeding via the PVN, has a short onset and duration of action and activates feeding by mechanisms independent to galanin and the melanocortin receptors. Expand
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TLDR
It is shown that one mRNA that is overexpressed in the hypothalamus of ob/ob mice encodes the neuropeptide melanin-concentrating hormone (MCH), which suggests that MCH participates in the leptin regulation of body weight. Expand
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TLDR
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TLDR
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