Acute and Chronic Cardiovascular Effects of Doxorubicin in the Dog: The Cardiovascular Pharmacology of Drug-Induced Histamine Release

@article{Bristow1980AcuteAC,
  title={Acute and Chronic Cardiovascular Effects of Doxorubicin in the Dog: The Cardiovascular Pharmacology of Drug-Induced Histamine Release},
  author={Michael R. Bristow and W Scott Sageman and Roderick H. Scott and Margaret E. Billingham and Ruth E. M. Bowden and Robert S. Kernoff and G H Snidow and John R. Daniels},
  journal={Journal of cardiovascular pharmacology},
  year={1980},
  volume={2 5},
  pages={487-515}
}
We evaluated the acute hemodynamic effects of doxorubicin in the open-chest dog. Doxorubicin at doses of 1-4 mg/kg administered over 2 min produced profound hemodynamic changes that were similar to those produced by histamine. These changes persisted despite administering the drug as a slow infusion. Histamine release in peripheral tissues was documented by a marked increase in venous histamine levels following doxorubicin administration. The heart extracted histamine during a period when… CONTINUE READING

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