Acute analgesic effects of nicotine and tobacco in humans: a meta-analysis.

@article{Ditre2016AcuteAE,
  title={Acute analgesic effects of nicotine and tobacco in humans: a meta-analysis.},
  author={Joseph W Ditre and Bryan W Heckman and Emily L. Zale and Jesse D Kosiba and Stephen A. Maisto},
  journal={Pain},
  year={2016},
  volume={157 7},
  pages={1373-81}
}
Although animal models have consistently demonstrated acute pain inhibitory effects of nicotine and tobacco, human experimental studies have yielded mixed results. The main goal of this meta-analysis was to quantify the effects of nicotine/tobacco administration on human experimental pain threshold and tolerance ratings. A search of PubMed and PsycINFO online databases identified 13 eligible articles, including k = 21 tests of pain tolerance (N = 393) and k = 15 tests of pain threshold (N = 339… CONTINUE READING
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