Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells.

@article{Arteel1996AcuteAP,
  title={Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells.},
  author={Gavin E. Arteel and James A. Raleigh and Blair U. Bradford and Ronald G. Thurman},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 1},
  pages={
          G494-500
        }
}
Previous studies using liver slices and isolated perfused rat liver have suggested that ethanol causes hypoxia by increasing oxygen consumption. However, ethanol also increases blood flow to the liver, a phenomenon that may counteract the effects of hypermetabolism by increasing oxygen delivery. Thus whether ethanol causes hypoxia in vivo remains unclear. To clarify this important point, female Sprague-Dawley rats (100-125 g) simultaneously received pimonidazole (120 mg/kg ip), a 2… 
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