Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection.

@article{Happel2006AcuteAI,
  title={Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection.},
  author={Kyle I. Happel and Anthony R. Odden and Ping Zhang and Judd E Shellito and Gregory J. Bagby and Steve Nelson},
  journal={Alcoholism, clinical and experimental research},
  year={2006},
  volume={30 7},
  pages={1200-7}
}
BACKGROUND Bacterial pneumonia is a widely recognized infection in the alcohol-abusing patient. Interleukin 23 (IL-23) is a recently described cytokine critical for IL-17 induction and host survival during Klebsiella pneumoniae infection, a pulmonary pathogen commonly seen in alcoholics. We investigated the effect of acute alcohol intoxication on the IL-23 response to this infection. METHODS Male C57BL/6 mice were given an intraperitoneal injection of ethanol (3.0 g/kg) or phosphate-buffered… CONTINUE READING