Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury.

@article{Li2008AcuteAI,
  title={Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury.},
  author={Xiaoling Li and Martin G. Schwacha and Irshad H. Chaudry and Mashkoor A. Choudhry},
  journal={Shock},
  year={2008},
  volume={29 3},
  pages={377-83}
}
This study examined whether acute alcohol (EtOH) intoxication before burn injury potentiates postburn intestinal tissue damage and whether neutrophils have any role in the damage under those conditions. Male rats ( approximately 250 g) were gavaged with EtOH to achieve a blood EtOH level of approximately 100 mg/dL or with saline and received either approximately 12.5% or approximately 25% total body surface area (TBSA) burn or sham injury. Rats were killed at 4 or 24 h after injury, and various… CONTINUE READING

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