Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

@article{Liu2009AcuteAO,
  title={Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine},
  author={Jing Liu and Jacob C. Garza and Jamaur Bronner and Chung Sub Kim and Wei Zhang and Xin-Yun Lu},
  journal={Psychopharmacology},
  year={2009},
  volume={207},
  pages={535-545}
}
Our previous studies in rats have shown that the adipocyte-derived hormone leptin induces antidepressant-like effects with a behavioral profile similar to selective serotonin reuptake inhibitor (SSRI) antidepressants. Acute SSRI treatment causes paradoxical anxiogenic responses, although chronic treatment has therapeutic effects on anxiety. However, the role of leptin in anxiety remains to be established. The scope of this study was to investigate the acute effects of leptin on anxiety-related… CONTINUE READING

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