Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone.

@article{Duffy1994AcuteAO,
  title={Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone.},
  author={D. Duffy and D. Hess and R. Stouffer},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 6},
  pages={
          1587-94
        }
}
  • D. Duffy, D. Hess, R. Stouffer
  • Published 1994
  • Medicine
  • The Journal of clinical endocrinology and metabolism
    • Colocalization of progesterone receptors and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD), a key enzyme in progesterone biosynthesis, in macaque luteal cells suggest that progesterone has an autocrine role in the regulation of primate luteal function. To test this hypothesis, we administered trilostane, a 3 beta HSD inhibitor, to rhesus macaques at the midluteal phase of spontaneous menstrual cycles to rapidly and reversibly reduce progesterone production. Animals received trilostane (600… CONTINUE READING
    View on PubMed
    doi.org
    73 Citations
    Background Citations
    23
    Methods Citations
    3
    Results Citations
    1
    73 Citations
    Citation Type

    Citation Type

    Dissociation of relaxin and progesterone secretion from the primate corpus luteum by acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor during the menstrual cycle.
    • 18
    • PDF
    Stimulation of primate luteal function by recombinant human chorionic gonadotropin and modulation of steroid, but not relaxin, production by an inhibitor of 3 beta-hydroxysteroid dehydrogenase during simulated early pregnancy.
    • 20
    • PDF
    Expression of steroid receptors and steroidogenic enzymes in the baboon (Papio anubis) corpus luteum during the menstrual cycle and early pregnancy.
    • 36
    • PDF
    Induced luteolysis in the primate: rapid loss of luteinizing hormone receptors.
    • 16
    • PDF
    Titrating luteinizing hormone replacement to sustain the structure and function of the corpus luteum after gonadotropin-releasing hormone antagonist treatment in rhesus monkeys.
    • 74
    • PDF
    Progesterone receptor messenger ribonucleic acid and protein in luteinized granulosa cells of rhesus monkeys are regulated in vitro by gonadotropins and steroids.
    • 38
    • PDF
    A Putative Stimulatory Role of Progesterone Acting via Progesterone Receptors in the Steroidogenic Cells of the Human Corpus Luteum1
    • 41
    • PDF
    Progesterone receptor messenger ribonucleic acid in the primate corpus luteum during the menstrual cycle: possible regulation by progesterone.
    • 57
    Expression of Estrogen Receptor α and β in the Rhesus Monkey Corpus Luteum during the Menstrual Cycle: Regulation by Luteinizing Hormone and Progesterone.
    • 60
    • PDF
    Steroidogenic enzyme expression in human corpora lutea in the presence and absence of exogenous human chorionic gonadotrophin (HCG).
    • 49
    • PDF