Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone.

@article{Duffy1994AcuteAO,
  title={Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone.},
  author={D. Duffy and D. Hess and R. Stouffer},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 6},
  pages={
          1587-94
        }
}
  • D. Duffy, D. Hess, R. Stouffer
  • Published 1994
  • Medicine
  • The Journal of clinical endocrinology and metabolism
  • Colocalization of progesterone receptors and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD), a key enzyme in progesterone biosynthesis, in macaque luteal cells suggest that progesterone has an autocrine role in the regulation of primate luteal function. To test this hypothesis, we administered trilostane, a 3 beta HSD inhibitor, to rhesus macaques at the midluteal phase of spontaneous menstrual cycles to rapidly and reversibly reduce progesterone production. Animals received trilostane (600… CONTINUE READING
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