Acute administration of THC impairs spatial but not associative memory function in zebrafish

@article{Ruhl2014AcuteAO,
  title={Acute administration of THC impairs spatial but not associative memory function in zebrafish},
  author={Tim Ruhl and Nicole Prinz and Nadine Oellers and Nathan Ian Seidel and Annika Jonas and {\"O}nder Albayram and Andras Bilkei-Gorzo and Gerhard von der Emde},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3829-3842}
}
RationaleThe present study examined the effect of acute administration of endocannabinoid receptor CB1 ligand ∆-9-tetrahydrocannabinol (THC) on intracellular signalling in the brain and retrieval from two different memory systems in the zebrafish (Danio rerio).MethodsFirst, fish were treated with THC and changes in the phosphorylation level of mitogen-activated protein (MAP) kinases Akt and Erk in the brain were determined 1 h after drug treatment. Next, animals of a second group learned in a… CONTINUE READING
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