Acute adenosinergic cardioprotection in ischemic-reperfused hearts.

@article{Headrick2003AcuteAC,
  title={Acute adenosinergic cardioprotection in ischemic-reperfused hearts.},
  author={John P Headrick and Ben Hack and Kevin John Ashton},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 5},
  pages={H1797-818}
}
Cells of the cardiovascular system generate and release purine nucleoside adenosine in increasing quantities when constituent cells are "stressed" or subjected to injurious stimuli. This increased adenosine can interact with surface receptors in myocardial, vascular, fibroblast, and inflammatory cells to modulate cellular function and phenotype. Additionally, adenosine is rapidly reincorporated back into 5'-AMP to maintain the adenine nucleotide pool. Via these receptor-dependent and… CONTINUE READING
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Cardioprotection with pre- and post-ischemic adenosine and A3 receptor activation: differing mechanisms and effects on necrosis versus stunning

  • A Flood, L Willems, JP. Headrick
  • Drug Develop Res
  • 2003
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