Acute activation of the adrenocorticotropin-adrenal axis: effect on gonadotropin and prolactin secretion in the female rat.

@article{Putnam1991AcuteAO,
  title={Acute activation of the adrenocorticotropin-adrenal axis: effect on gonadotropin and prolactin secretion in the female rat.},
  author={C D Putnam and Darrell W Brann and Virendra B. Mahesh},
  journal={Endocrinology},
  year={1991},
  volume={128 5},
  pages={2558-66}
}
The purpose of this study was to examine the effect of a single injection of ACTH-(1-39) on gonadotropin secretion in the estrogen-primed intact and ovariectomized female rat and to determine if the effect of ACTH was mediated through the release of adrenal steroids. Administration of 100 micrograms ACTH-(1-39/rat caused a significant elevation in serum LH and FSH levels 6 h after injection. This stimulatory action of ACTH was abolished by adrenalectomy in both intact and ovariectomized rats… CONTINUE READING