Acute acidic exposure induces p53-mediated oxidative stress and DNA damage in tilapia (Oreochromis niloticus) blood cells.

@article{Mai2010AcuteAE,
  title={Acute acidic exposure induces p53-mediated oxidative stress and DNA damage in tilapia (Oreochromis niloticus) blood cells.},
  author={Wei-jun Mai and Jun-lun Yan and Lei Wang and Ying Zheng and Y P Xin and Wei-Na Wang},
  journal={Aquatic toxicology},
  year={2010},
  volume={100 3},
  pages={271-81}
}
Acid rain and inputs of acidic effluent can result in increased acidity in aquatic ecosystems, where it is known to have a significant impact and possibly, to cause the decline of some populations of aquatic organisms. In previous studies, intracellular acid-induced oxidative stress has been shown to cause DNA damage, and cooperatively activate the expression of the p53 gene. The acute effects of acidic environments on shrimp and fish have been widely studied. However, the molecular mechanism… CONTINUE READING

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