Acute acid aspiration lung injury in the rat: biphasic pathogenesis.

  title={Acute acid aspiration lung injury in the rat: biphasic pathogenesis.},
  author={Thomas P Kennedy and Kent J. Johnson and Robin G. Kunkel and Peter A Ward and Paul Knight and Joanne S Finch},
  journal={Anesthesia and analgesia},
  volume={69 1},
The purpose of this study was to develop a reproducible model of acute acid aspiration-induced lung injury in the rat to explore the pathophysiology of aspiration pneumonitis. A biphasic injury pattern was observed with injury peaks at 1 hr and 4 hr. Histologic studies at 4 hr revealed significant increases in neutrophils in the alveolar interstitial space. These studies suggest that acid aspiration results in a biphasic acute injury. We hypothesize that the first phase results from a direct… CONTINUE READING

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