Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes

@inproceedings{Makino2016AcuteAO,
  title={Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes},
  author={Asami Makino and Françoise Hullin-Matsuda and Motohide Murate and Mitsuhiro Abe and Nario Tomishige and Mitsunori Fukuda and Shizuya Yamashita and Toyoshi Fujimoto and H. Zuniga Vidal and Michel Guichardant andMichel Lagarde and Isabelle Delton and Toshihide Kobayashi},
  booktitle={Molecular biology of the cell},
  year={2016}
}
Dysregulated hepatic cholesterol homeostasis with free cholesterol accumulation in the liver is relevant to the pathogenesis of nonalcoholic steatohepatitis, contributing to the chronicity of liver toxicity. Here we examined the effect of free cholesterol accumulation on the morphology and biochemical properties of lipid droplets (LDs) in cultured hepatocytes. Acute free cholesterol accumulation induced the fusion of LDs, followed by degradation of the coat protein of LDs, perilipin 2 (PLIN2… CONTINUE READING
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SHOWING 1-10 OF 47 REFERENCES

Cholesterol controls lipid endocytosis through Rab11.

  • Molecular biology of the cell
  • 2007
VIEW 8 EXCERPTS
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