Acute Voluntary Intoxication by Ricin

@article{Kopferschmitt1983AcuteVI,
  title={Acute Voluntary Intoxication by Ricin},
  author={Jacques Kopferschmitt and Françoise Flesch and A. A. J. Lugnier and Philippe Sauder and Albert Jaeger and J. M. Mantz},
  journal={Human and Experimental Toxicology},
  year={1983},
  volume={2},
  pages={239 - 242}
}
1 A 21 year-old student ingested thirty ricin seeds in a suicidal attempt, some of which were masticated. Three hours later he developed severe diarrhoea with vomiting and abdominal cramps, followed by extracellular dehydration and circulatory collapse. 2 Biological changes included haemoconcentration. He recovered following symptomatic treatment by infusion of saline and glucose solutions. 3 Ricin was quantified by a radioimmunologic method using Iodine 125, and showed that only a small part… 
View on SAGE
ncbi.nlm.nih.gov
59 Citations
Background Citations
7
Methods Citations
2

59 Citations

Hepatotoxicity from Castor Bean Ingestion in a Child

It seems prudent to follow for several days any patients who actually chewed castor beans before ingestion to see if they developed reversible hepatotoxicity beginning 48–72 hours after the ingestion ofCastor beans.

Castor bean poisoning.

Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract—a case study

Results indicated approximately uniform distribution of ricinine in the body after death, and the GC-MS method was applied for the analysis of extract of castor seed and the patient’s urine, to demonstrate alternative possibility for identification of Ricinine for clinical and forensic purposes.

Near-fatal poisoning after ricin injection

Ricin injection resulted in a near-fatal poisoning that evolved with septic shock-like syndrome, multiple organ dysfunction and necrotizing fasciitis, all of which were successfully treated with supportive care.

Infectious and toxic cellulitis due to suicide attempt by subcutaneous injection of ricin

A 53-year-old man with depression who had decided to commit suicide and had taken 13 castor beans, chewed them, and injected the product of mastication into the inner side of his left thigh was admitted for cellulitis of the thigh.

Ricinus communis Intoxications in Human and Veterinary Medicine-A Summary of Real Cases

Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries but the causative agent remained elusive until 1888 when Stillmark attributed the toxicity…

7. Sub-Lethal Poisoning by Self-Injection with Ricin

A case of sub-lethal poisoning by self-injection of ricin, one of the most potent toxins known, is reported.

Castor bean intoxication.

Evaluation of ricinine, a ricin biomarker, from a non-lethal castor bean ingestion.

A case is presented of the attempted suicide of a 58-year-old man using castor beans. The patient came to the emergency room complaining of nausea, vomiting and diarrhea for nine hours following the…

Serial ricinine levels in serum and urine after ricin intoxication.

Serial ricinine levels are reported in the serum and urine of a patient suffering from intentional ricin intoxication, which resulted in the patient dying 38 h later, despite intensive medical care.
...

References

SHOWING 1-9 OF 9 REFERENCES

Abrus and ricinus ingestion: management of three cases.

One case of jequirty bean and two of castor bean were treated at Cardial Glennon Memorial Hospital for Children during the third week of August in 1979.

Radioimmunoassays of abrin and ricin in blood.

The procedures described are capable of determining blood concentrations down to 50-100 pg/ml, permitting identification of abrin and ricin poisoning and monitoring of the blood concentrations in cancer patients treated with these agents.

A comparison of the accumulation of ricin by hepatic parenchymal and non-parenchymal cells and its inhibition of protein synthesis.

Ricinus poisoning: a familiar epidemy.

Toxicity of abrin and ricin in mice and dogs.

The results indicate that in mice and dogs given sublethal doses of highly purified toxins the symptoms are reversible and there was no finding militating against a phase 1 clinical trial.

Ricin: the toxic protein of castor oil seeds.

Abrus and ricinus ingestion

  • 1980

Poisonous and injurious higher plants and fungi

  • Forensic Medicine
  • 1977

Ricin - a patent homicidal poison

  • Brit . Med . J .
  • 1979