Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

@inproceedings{Hall2013AcuteVC,
  title={Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes},
  author={Emma A. Hall and Margaret Anne Keighren and Matthew J. Ford and Tracey L Davey and Andrew Paul Jarman and Lee B. Smith and Ian J Jackson and Pleasantine Mill},
  booktitle={PLoS genetics},
  year={2013}
}
Defects in cilium and centrosome function result in a spectrum of clinically-related disorders, known as ciliopathies. However, the complex molecular composition of these structures confounds functional dissection of what any individual gene product is doing under normal and disease conditions. As part of an siRNA screen for genes involved in mammalian ciliogenesis, we and others have identified the conserved centrosomal protein Azi1/Cep131 as required for cilia formation, supporting previous… CONTINUE READING
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