Acute Treatment with Candesartan Reduces Early Injury After Permanent Middle Cerebral Artery Occlusion

@article{Guan2010AcuteTW,
  title={Acute Treatment with Candesartan Reduces Early Injury After Permanent Middle Cerebral Artery Occlusion},
  author={Weihua Guan and Anna Kozak and Azza B El-Remessy and Maribeth H. Johnson and Bindu A. Pillai and Susan C Fagan},
  journal={Translational Stroke Research},
  year={2010},
  volume={2},
  pages={179-185}
}
We have shown that reduction of blood pressure (BP) immediately after the onset of reperfusion reduced neurovascular damage and improved functional outcome after experimental cerebral ischemia and candesartan is particularly effective in improving long-term functional outcome. In this study, we sought to determine if early BP lowering with candesartan, in the presence of an occluded cerebral artery, will reduce injury and improve outcome after experimental stroke. Male Wistar rats underwent 24… CONTINUE READING
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