Acute Toxicity of 3,4-Methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti Rats

@article{Malpass1999AcuteTO,
  title={Acute Toxicity of 3,4-Methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti Rats},
  author={Alice Malpass and Jill M. White and Rodney James Irvine and Andrew A Somogyi and Felix Bochner},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={64},
  pages={29-34}
}
Ingestion of MDMA ("ecstasy") by humans can cause acute toxicity manifested by hyperthermia and death. Demethylenation of MDMA is catalyzed by cytochrome P-450 2D6 (CYP2D6) and cytochrome P-450 2D1 (CYP2D1) in humans and rats, respectively, and is polymorphically expressed. It has been proposed that CYP2D6 deficiency may account for the unexplained toxicity of MDMA. The female Dark Agouti rat is deficient in CYP2D1, and serves as a model for the human poor metabolizer. We investigated… CONTINUE READING

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Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.

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  • 2010
VIEW 1 EXCERPT
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3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brain.

  • The international journal of neuropsychopharmacology
  • 2007
VIEW 2 EXCERPTS
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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

An appraisal of the pharmacological and toxicological effects of a single oral administration of 3 , 4 - methylenedioxymethamphet - amine ( MDMA ) in the rat

I. DeSouza, J. P. Kelly, A. J. Harkin, B. E. Leonard
  • Pharmacol . Toxicol .
  • 1997