Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats

  title={Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats},
  author={Mohamed M. Ibrahim and Hapipah Binti Mohd Ali and Mahmood Ameen Abdullah and Pouya Hassandarvish},
  pages={12449 - 12459}
The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment… 
In vivo acute toxicity and anti-gastric evaluation of a novel dichloro Schiff base: Bax and HSP70 alteration
Histological evaluations showed that the gastroprotective property of a novel dichloro-substituted Schiff base complex, 2, 2′- [−1, 2-cyclohexanediylbis(nitriloethylidyne)] bis(4-chlorophenol) (CNCP), against alcohol-induced gastric lesion in SD rats was assessed and it was shown that the compound possesses stomach epithelial defense activity.
Gastroprotective Activity of Ethyl-4-[(3,5-di-tert-butyl-2-hydroxybenzylidene) Amino]benzoate against Ethanol-Induced Gastric Mucosal Ulcer in Rats
Protection of gastric mucosa was revealed as ascertained by significant increases in superoxide dismutase (SOD), pH level, mucus secretion, reduced gastric lesions, malondialdehyde (MDA) level and remarkable flattened gastrics mucosa.
Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl/Ethanol-Induced Gastric Mucosal Damage In Rats
TIBH showed a ulcer prevention potential by increase of the mucus secretion, decrease of the gastric acidity, up-regulation of HSP70 protein, down- regulation of Bax protein, decrease in the lipid peroxidation and the increase in the Superoxide dismutase activity in gastric tissue homogenate.
The anti-ulcer activity of the Schiff base : 1 H-indole-3-ethylenesalicyldamine and its zinc ( II ) , nickel ( II ) and copper ( II ) complexes
The anti-ulcer effect of the Schiff base 1H-indole-3-ethylenesalicyldamine and its zinc (II), nickel (II) and copper (II) complexes have been reported. The compounds were tested against
The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats
The gastroprotective activity of this plant might be related to increased antioxidant enzymes and decrease lipid peroxidation upsurge of HSP70 and reduced expression of Bax proteins.
The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer
Grossly, the data demonstrated a significant decrease in the ulcer area of rats pretreated with plant extract in a dose-dependent manner with respect to the ulcers of ulcerated group.
Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion
The results showed that the Schiff base metal derivatives enhanced the expression of HSP70 and suppressed theexpression of BAX proteins during their gastroprotection against ethanol-induced gastric lesion in rats.
Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base
It is concluded that complexes MC1 and MC2 may be used as potent antimicrobial and anticorrosion agents, respectively.
New applied pharmacological approach/trend on utilization of agro-industrial wastes
Results revealed that methylcellulose, sulfated and phosphorylated hemicelluloses showed anti-inflammatory and gastroprotective activities and the capability of all tested compounds to ameliorate the ethanol-induced gastric ulcer in rats’ stomach.
Structural and Biological Studies on Transition Metal Complexes of 4-Aminoantipyrine Derivative
Novel tetra dentate Cu(II), Ni(II), Co(II), VO(II) and Zn(II) Schiff base complexes have been synthesized from salicylidene-4-iminoantipyrine and tyrosine. The synthesized Schiff base complexes was


Synthesis, structural characterization, and anti-ulcerogenic activity of schiff base ligands derived from tryptamine and 5-chloro, 5-nitro, 3,5-ditertiarybutyl salicylaldehyde and their nickel(II), copper(II), and zinc(II) complexes
Abstract Ni(II), Cu(II), and Zn(II) complexes with bidentate Schiff bases derived from the condensation reaction of 5-chlorosalicylaldehyde, 5-nitrosalicylaldehyde, and 3,5 ditertiarybutyl-2-hydroxy
Prostaglandins and nitric oxide in copper-complex mediated protection against ethanol-induced gastric damage.
The role of PGE2 and nitric oxide and the involvement of endogenous eicosanoids and NO was evaluated with the respective inhibitors of prostaglandin and NO synthesis, indomethacin and NG-nitro-L-arginine, suggesting that prostanoids contribute to the Cu(II)(L-Trp)( L-Phe) protective effect, together with some mechanism(s) other than NO synthesis.
Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa.
The cytoprotective effect of Cu(II) complexes against ethanol-induced mucosal lesions was not associated in vivo to lipid peroxidation, suggesting that nontoxic copper(II)-amino acid complexes are able to neutralize oxygen-derived free radicals.
Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats.
It is suggested that the mechanism of protection would involve, at least in part, a nucleophylic attack of the sulfhydryl group from the biological molecules present in the gastric mucosa to electrophylic carbons accessible in suitable Michael acceptors.
Menadione protects gastric mucosa against ethanol-induced ulcers.
  • M. Tariq, A. A. Al Moutaery
  • Biology, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2005
Pretreatment of rats with menadione significantly protected gastric mucosa against ethanol-induced gastric lesion and acid antisecretory and antiulcer activity ofMenadione was clearly showed.
Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.
Oral administration of oleo-resin provided dose-dependent significant protection against gastric damage caused by ethanol and restraint stress, and at a dose of 400 mg/kg it also prevented the gastric ulceration induced by indomethacin.
Effects of leminoprazole, omeprazole and sucralfate on indomethacininduced delayed healing of kissing gastric ulcers in rats
Results suggested that leminoprazole and omeprazole prevent the indomethacin‐induced delay in ulcer healing by promoting tissue contraction and regeneration of the ulcerated mucosa and MPO activity will be useful to biochemically ensure the healing state of ulcers.
Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone.
It was found that pretreatment of rats with 1 caused a significant increase in glycoprotein synthetic activity, approximately sevenfold as large as that of the control, and the protective effect of 1 was not totally abolished by pretreatment with a combination of indomethacin and NEM, indicating additional mechanisms are involved in the cytoprotective action of 1.
Effect of salvianolic acid A, a depside from roots of Salvia miltiorrhiza, on gastric H+,K(+)-ATPase.
The results suggest that salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H+,K(+)-ATPase.
Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats.
It is suggested that CE prevented ethanol induced gastric mucosal lesions by strengthening the mucosal barrier and reducing the damaging effects of free radicals.