Acute T3 treatment protects the heart against ischemia-reperfusion injury via TRα1 receptor

@article{Pantos2011AcuteTT,
  title={Acute T3 treatment protects the heart against ischemia-reperfusion injury via TRα1 receptor},
  author={Constantinos Pantos and Iordanis Mourouzis and Theodosios Saranteas and Vassiliki Brozou and Georgios Galanopoulos and Georgia Kostopanagiotou and Dennis Vassilios Cokkinos},
  journal={Molecular and Cellular Biochemistry},
  year={2011},
  volume={353},
  pages={235-241}
}
We have previously shown that acute thyroid hormone treatment could limit reperfusion injury and increase post-ischemic recovery of function. In the present study, we further explore potential initiating mechanisms of this response. Thus, isolated rat hearts were subjected to 30 min zero-flow global ischemia (I) followed by 60-min reperfusion (R). Reperfusion injury was assessed by post-ischemic recovery of left ventricular developed pressure (LVDP%) and LDH release. T3 at a dose of 60nM which… CONTINUE READING

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Thyroid Hormone and Cardioprotection.

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