Acute Stress Impairs Hippocampal Mossy Fiber-CA3 Long-Term Potentiation by Enhancing cAMP-Specific Phosphodiesterase 4 Activity

@article{Chen2010AcuteSI,
  title={Acute Stress Impairs Hippocampal Mossy Fiber-CA3 Long-Term Potentiation by Enhancing cAMP-Specific Phosphodiesterase 4 Activity},
  author={Chien-Chung Chen and Chih-hao Yang and C C Huang and Kuei-sen Hsu},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1605-1617}
}
The mossy fiber synapses onto hippocampal CA3 neurons show unique molecular features and a wide dynamic range of plasticity. Although acute stress has been well recognized to alter bidirectional long-term synaptic plasticity in the hippocampal CA1 region and dentate gyrus, it remains unclear whether the same effect may also occur at the mossy fiber-CA3 synapses. Here, we report that hippocampal slices prepared from adult mice that had experienced an acute unpredictable and inescapable restraint… CONTINUE READING

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