Acute Respiratory Distress Syndrome

@article{Thompson2017AcuteRD,
  title={Acute Respiratory Distress Syndrome},
  author={Taylor B. Thompson and Rachel C. Chambers and Kathleen D. Liu},
  journal={The New England Journal of Medicine},
  year={2017},
  volume={377},
  pages={562–572}
}
From the Division of Pulmonary and Crit­ ical Care, Department of Medicine, Mas­ sachusetts General Hospital, and Har­ vard Medical School — both in Boston (B.T.T.); Centre for Inflammation and Tis­ sue Repair, the Division of Medicine, Uni­ versity College London, London (R.C.C.); and the Divisions of Nephrology and Critical Care Medicine, University of California San Francisco, San Francisco (K.D.L.). Address reprint requests to Dr. Thompson at the Division of Pulmonary and Critical Care… Expand

Paper Mentions

Interventional Clinical Trial
Through its anti-inflammatory role, molecular hydrogen could have a beneficial effect in preventing the runaway inflammatory reactions that lead to complications of Covid-19… Expand
ConditionsAMBULATORY CARE, Covid19, SARS-CoV-2
InterventionDietary Supplement
Observational Clinical Trial
The acute respiratory distress syndrome (ARDS) is a life-threatening disease with functional impairment of the lung. It is characterized by an excessive inflammatory response of lung… Expand
ConditionsARDS
InterventionDiagnostic Test
A Review of Acute Respiratory Distress Syndrome Management and Treatment.
  • Z. Hasan
  • Medicine
  • American journal of therapeutics
  • 2021
TLDR
Patients with ARDS have a high mortality due to the incredibly complex disease process and some of the strategies used to date, including the role of ECMO, are reviewed, and some society recommendations are included. Expand
Acute respiratory distress syndrome
TLDR
Treatment focuses on lung-protective ventilation; no specific pharmacotherapies have been identified and long-term outcomes of patients with ARDS are increasingly recognized as important research targets. Expand
2021 Acute Respiratory Distress Syndrome Update, With Coronavirus Disease 2019 Focus
TLDR
COVID-19 ARDS has some distinguishing features from traditional ARDS, including delayed onset, hyperinflammatory response, and pulmonary microthrombi, and should be treated with established supportive therapies. Expand
Management of ARDS – What Works and What Does Not
TLDR
A detailed review of the literature including the most up-to-date studies and guidelines in the management of acute respiratory distress syndrome is presented. Expand
Approaches and techniques to avoid development or progression of acute respiratory distress syndrome
TLDR
There is potential for improvement in the management of patients admitted to intensive care unit to reduce ARDS incidence and apart from nonspecific measures, prevention of ventilator-induced lung injury and patient self-inflicted lung injury are of major importance. Expand
Pathobiology of Pediatric Acute Respiratory Distress Syndrome
TLDR
With multiple causes and pathobiologic mechanisms, resolving the initial injury and restoring normal lung architecture and function are complex processes that have been difficult to model experimentally, making extrapolation of knowledge gained from adult clinical and laboratory models to children challenging. Expand
Corticosteroids in the Management of Pregnant Patients With Coronavirus Disease (COVID-19).
TLDR
The objective is to summarize the current evidence supporting steroid therapy in the management of patients with acute respiratory distress syndrome and COVID-19 and to elaborate on key modifications for the pregnant patient. Expand
Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: The Doctors are In, but the Jury is Still Out
  • D. Wacker
  • Medicine
  • Clinical Pulmonary Medicine
  • 2019
TLDR
The risks and benefits of ECMO for the treatment of ARDS are outlined, the body of evidence behind this practice is examined, including 4 randomized controlled trials and 2 case-controlled studies, and the remaining questions and directions for future research are discussed. Expand
Case Report: Typhoid Fever Complicated by Acute Respiratory Distress Syndrome in a Pediatric Traveler: A Case Report and Review of the Literature.
TLDR
An 8-year-old boy with TF after return from India who developed pediatric ARDS (pARDS) despite adequate antibiotic treatment is reported, raising important questions regarding the frequency, pathophysiology, and appropriate management of ARDS and pARDS in patients with TF. Expand
Salvage therapies for refractory hypoxemia in ARDS.
TLDR
All the salvage therapies described have been associated with improved oxygenation, but with the exception of proning and 48 h of paralysis early in the course of ARDS, none of them have a proven mortality benefit. Expand
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References

SHOWING 1-10 OF 66 REFERENCES
High-Frequency Oscillation for Acute Respiratory Distress Syndrome
TLDR
This work presents a meta-analysis of clinical trials and animal studies that show clear trends in survival and morbidity in neonatal intensive care unit admissions and suggest that admissions to intensive care units are higher in women than in men. Expand
Acute respiratory distress in adults.
TLDR
Positive end-expiratory pressure was most helpful in combating atelectasis and hypoxaemia and Corticosteroids appeared to have value in the treatment of patients with fat-embolism and possibly viral pneumonia. Expand
Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition.
TLDR
The Berlin definition is likely to underestimate the impact of ARDS in low-income countries, where resources to meet the definition requirements are lacking and further work in refining an ARDS definition that can be consistently used in all settings is stimulated. Expand
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.
TLDR
Methylprednisolone increased the number of ventilator-free and shock-free days during the first 28 days in association with an improvement in oxygenation, respiratory-system compliance, and blood pressure with fewer days of vasopressor therapy and did not increase the rate of infectious complications but was associated with a higher rate of neuromuscular weakness. Expand
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
TLDR
Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS. Expand
Comparison of Clinical Criteria for the Acute Respiratory Distress Syndrome with Autopsy Findings
TLDR
The criterion validity of the definition of ARDS proposed by the AmericanEuropean Consensus Conference was evaluated by using autopsy findings as the reference standard and whether the validity of this definition was modified according to the presence of pulmonary or extrapulmonary risk factors. Expand
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), andExpand
Fifty Years of Research in ARDS. Is Acute Respiratory Distress Syndrome a Preventable Disease?
TLDR
In this review, the rationale, current evidence, and future directions in ARDS prevention are summarized. Expand
Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy.
RATIONALE A revised definition of clinical criteria for acute respiratory distress syndrome (ARDS), the Berlin definition, was recently established to classify patients according to their severity.Expand
Acute respiratory distress syndrome mimics: the role of lung biopsy
TLDR
An ARDS mimic enhances the need of making ARDS diagnosis as comprehensive as possible, and why the complete diagnosis of ARDS is important is discussed, and the role of open lung biopsy in this setting is discussed. Expand
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