Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

@article{Juss2016AcuteRD,
  title={Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.},
  author={Jatinder K. Juss and David R.C. House and Augustin Amour and Malcolm Begg and Jurgen Herre and Daniel Storisteanu and Kim Hoenderdos and Glyn Bradley and Mark M. Lennon and Charlotte Summers and Edith M Hessel and Alison M Condliffe and Edwin R Chilvers},
  journal={American journal of respiratory and critical care medicine},
  year={2016},
  volume={194 8},
  pages={961-973}
}
RATIONALE Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES To examine the functional and transcriptional profiles of patient blood and alveolar neutrophils compared with healthy volunteer cells, and to define their sensitivity to phosphoinositide 3-kinase inhibition. METHODS Twenty-three… CONTINUE READING
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