Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases

  title={Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases},
  author={Alan Ronald Talbot and Mon-Han Shiaw and Jinn-Sheng Huang and Shu-Fen Yang and T S Goo and Shur-Hueih Wang and Chao-Liang Chen and Thomas R. Sanford},
  journal={Human \& Experimental Toxicology},
  pages={1 - 8}
Between 1 January 1980, and 30 September 1989, 93 cases of exposure to herbicides containing glyphosphate and surfactant ('Roundup') were treated at Changhua Christian Hospital. The average amount of the 41% solution of glyphosate herbicide ingested by non-survivors was 184 ± 70 ml (range 85-200 ml), but much larger amounts (500 ml) were reported to have been ingested by some patients and only resulted in mild to moderate symptomatology. Accidental exposure was asymptomatic after dermal contact… 
The epidemiology of glyphosate-surfactant herbicide poisoning in Taiwan, 1986–2007: a poison center study
Age, ingested amount, delayed presentation, and reason for exposure were likely to be determinants of the severity of GlySH exposure, and prompt fluid replacement therapy seems critical in the initial management of such exposures.
Fatal Poisoning with Glyphosate-Surfactant Herbicide
A 29-year-old man was admitted following deliberate ingestion of ‘Roundup Ace,’ a herbicide containing glyphosate, and rapidly developed multi-organ failure, culminating in his death.
Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases.
In managing patients who have larger amount of GlySH ingestion, airway protection, early detection of pulmonary edema, and prevention of further pulmonary damage and renal damage appear to be of critical importance.
Pathological and Toxicological Findings in Glyphosate-Surfactant Herbicide Fatality: A Case Report
It is proposed that the characteristic picture of microvesicular steatosis of the hepatocytes, seen predominantly in centrilobular zones of the liver, resembled drug-induced hepatic toxicity or secondary hypoxic stress.
Acute Poisoning with Herbicide Glyphosate
In this shown case poisoning was caused during applying herbicides without proper handling with the herbicide and also because of non-compliance of measures in safety and health at work.
Acute poisoning with a herbicide containing imazapyr (Arsenal): a report of six cases.
It appeared the toxic syndrome that results from a large quantity of Arsenal herbicide ingestion consists of hypotension, pulmonary dysfunction, oral mucosal and gastrointestinal irritation, and transient liver and renal dysfunction.
Rapid lethal intoxication caused by the herbicide glyphosate-trimesium (Touchdown)
It is proposed that containers with glyphosate-trimesium must be labelled because of the apparent effect of lethal intoxication, and it is suggested that the lethal mechanism between the two herbicides may be different.
Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning
The findings suggest that the present case involved aseptic meningitis in association with GlySH poisoning, which should be considered in cases of glyphosate-surfactant herbicide poisoning.
Hemodialysis clearance of glyphosate following a life-threatening ingestion of glyphosate-surfactant herbicide
The successful clearance of glyphosate is demonstrated using hemodialysis, with corresponding clinical improvement in a patient with several poor prognostic factors (advanced age, large volume ingested, and impaired consciousness).
Severe acute poisoning due to a glufosinate containing preparation without mitochondrial involvement
A 41-year-old woman who ingested between 30 and 50 mL of a herbicide containing glufosinate in a suicide attempt was extubated without complications and the evolution was favorable, but the sinus bradycardia persisted up to 8 days after the ingestion.


Phototoxicity of glyphosate in a weedkiller
It is believed that a coconut-oil-based body lotion used in the showers is a likely cause of the fragrance sensitivity seen in miners, and this would explain the more normal fragrance mix result seen in a small group of ex-miners.
The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase.
Phototoxicity of a weedkiller: a correction
A comparison study of sensitisation capacity of epoxy resin oligomers in the guinea pig with respect to the role played by Bisphenol-A and its applications in the citrus fruit industry and cross sensitisation to dinestrol and hexestrol.
The determination of paraquat (I,I'-dimethyl-4,4'-bipyridylium cation) in urine.
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Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.
The results indicate that phenoxyacetic acids, especially MCPA, may have potent effects on the metabolism of xenobiotics and Glyphosate, not chemically related to Phenoxyacids, seems to inhibit monooxygenases.
Rapid determination of glyphosate in postmortem specimens using 31P NMR.
Glyphosate was quantified, using 31P NMR, in postmortem blood, liver, and urine specimens taken from two suicide victims, confirmed by its characteristic 31P chemical shift and proton spin coupling and by a downfield shift on addition of NH4OH.
Objective radiographic criteria to differentiate cardiac, renal, and injury lung edema.
A standardized reading of chest radiographs may be considered a reliable clinical method for identifying pulmonary edema etiology.