Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs

@article{Vale1986AcutePD,
  title={Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs},
  author={J Allister Vale and Ted Jordan Meredith},
  journal={Medical Toxicology},
  year={1986},
  volume={1},
  pages={12-31}
}
SummaryDespite the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), the current number of reported cases of poisoning is small However, with the introduction of ‘over-the-counter’ preparations of NSAIDs in some countries (e.g. ibuprofen in the UK and USA) an increased incidence of acute poisoning from this group of drugs can be expected. Conventionally, NSAIDs are divided into the following groups based on their chemical structure: arylpropionic acids, indole and indene acetic… Expand
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13 – Minor analgesics and non-steroidal anti-inflammatory drugs
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Signs and symptoms of acute poisoning with NSAIDs include nausea, vomiting, headache, drowsiness, blurred vision, and dizziness, and treatment is largely supportive. Expand
Toxic Effects of Nonsteroidal Anti-Inflammatory Drugs in Overdose
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Most NSAID overdoses result in a benign outcome, but isolated case reports have documented serious toxicity, such as seizures, hypotension, apnoea, coma and renal failure. Expand
The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose
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There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. Expand
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Research relating to these adverse drug reactions, focusing on histopathological findings, which may contribute to the comprehension and possible avoidance of drug-induced disease is reviewed. Expand
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SummaryThe authors challenge the general view that the analgesic effect of the nonsteroidal anti-inflammatory drugs (NSAIDs) can be universally attributed to their inhibitory effects on the synthesis… Expand
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A case of perforated duodenal ulcer following acute overdose of ibuprofen in a patient with no other identified risk factors is described. Expand
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  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1990
TLDR
The article outlines the incidence, clinical toxicity, mode of action, and pharmacokinetics of nonsteroidal antiinflammatory drugs and general management recommendations for the treatment of NSAID toxicoses. Expand
Severe metabolic acidosis after acute naproxen sodium ingestion.
TLDR
The case of a 15-year-old girl who presented with severe metabolic acidosis and seizures that rapidly followed naproxen sodium ingestion is reported, and serum bicarbonate levels returned to normal 12 hours after admission and correlated with the known pharmacokinetics of Naproxen. Expand
Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
TLDR
Renal impairment after acute overdoses of nonsteroidal anti-inflammatory drugs was generally transient but in one case was treated by hemodialysis and one by continuous arterio-venous hemofiltration dialysis, and the risk of acute renal dysfunction must be considered. Expand
Dextropropoxyphene Overdose
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The importance of early diagnosis and treatment is stressed in view of the potentially lethal complications that may suddenly occur with this poisoning and caution is advised regarding the prescription for ‘at risk’ patients of alternative analgesics, which may be no safer in overdosage. Expand
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