Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs
@article{Vale1986AcutePD, title={Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs}, author={J Allister Vale and Ted Jordan Meredith}, journal={Medical Toxicology}, year={1986}, volume={1}, pages={12-31} }
SummaryDespite the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), the current number of reported cases of poisoning is small However, with the introduction of ‘over-the-counter’ preparations of NSAIDs in some countries (e.g. ibuprofen in the UK and USA) an increased incidence of acute poisoning from this group of drugs can be expected. Conventionally, NSAIDs are divided into the following groups based on their chemical structure: arylpropionic acids, indole and indene acetic…
51 Citations
Toxic Effects of Nonsteroidal Anti-Inflammatory Drugs in Overdose
- MedicineDrug safety
- 1990
Most NSAID overdoses result in a benign outcome, but isolated case reports have documented serious toxicity, such as seizures, hypotension, apnoea, coma and renal failure.
The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose
- MedicineOpen access emergency medicine : OAEM
- 2011
There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions.
Toxicopathological overview of analgesic and anti-inflammatory drugs in animals
- Medicine, Biology
- 2012
Research relating to these adverse drug reactions, focusing on histopathological findings, which may contribute to the comprehension and possible avoidance of drug-induced disease is reviewed.
Dissociation Between the Antinociceptive and Anti-Inflammatory Effects of the Nonsteroidal Anti-Inflammatory Drugs
- Biology, MedicineDrugs
- 2012
SummaryThe authors challenge the general view that the analgesic effect of the nonsteroidal anti-inflammatory drugs (NSAIDs) can be universally attributed to their inhibitory effects on the synthesis…
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Severe metabolic acidosis after acute naproxen sodium ingestion.
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Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
- MedicineJournal of toxicology. Clinical toxicology
- 1995
Renal impairment after acute overdoses of nonsteroidal anti-inflammatory drugs was generally transient but in one case was treated by hemodialysis and one by continuous arterio-venous hemofiltration dialysis, and the risk of acute renal dysfunction must be considered.
IBUPROFEN INDUCED HEMOGLOBINURIA- CASE REPORT
- Medicine
- 2016
It is found that Suprofen a drug very similar to ibuprofen has caused hemoglobinuria, and the preventability and severity assessments as per the hartwig scale revealed the ADR to be “not preventable.
Suspected Central Nervous System Toxicity from Inadvertent Nonsteroidal Antiinflammatory Drug Overdose
- MedicineDICP : the annals of pharmacotherapy
- 1991
This case illustrates a severe adverse reaction of the central nervous system involving a moderate overdose of diclofenac sodium along with therapeutic dosages of indomethacin and ibuprofen. Our…
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