Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs

  title={Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs},
  author={J Allister Vale and Ted Jordan Meredith},
  journal={Medical Toxicology},
SummaryDespite the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), the current number of reported cases of poisoning is small However, with the introduction of ‘over-the-counter’ preparations of NSAIDs in some countries (e.g. ibuprofen in the UK and USA) an increased incidence of acute poisoning from this group of drugs can be expected. Conventionally, NSAIDs are divided into the following groups based on their chemical structure: arylpropionic acids, indole and indene acetic… 
Toxic Effects of Nonsteroidal Anti-Inflammatory Drugs in Overdose
Most NSAID overdoses result in a benign outcome, but isolated case reports have documented serious toxicity, such as seizures, hypotension, apnoea, coma and renal failure.
The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose
There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions.
Toxicopathological overview of analgesic and anti-inflammatory drugs in animals
Research relating to these adverse drug reactions, focusing on histopathological findings, which may contribute to the comprehension and possible avoidance of drug-induced disease is reviewed.
Dissociation Between the Antinociceptive and Anti-Inflammatory Effects of the Nonsteroidal Anti-Inflammatory Drugs
SummaryThe authors challenge the general view that the analgesic effect of the nonsteroidal anti-inflammatory drugs (NSAIDs) can be universally attributed to their inhibitory effects on the synthesis
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Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
Renal impairment after acute overdoses of nonsteroidal anti-inflammatory drugs was generally transient but in one case was treated by hemodialysis and one by continuous arterio-venous hemofiltration dialysis, and the risk of acute renal dysfunction must be considered.
It is found that Suprofen a drug very similar to ibuprofen has caused hemoglobinuria, and the preventability and severity assessments as per the hartwig scale revealed the ADR to be “not preventable.
Suspected Central Nervous System Toxicity from Inadvertent Nonsteroidal Antiinflammatory Drug Overdose
This case illustrates a severe adverse reaction of the central nervous system involving a moderate overdose of diclofenac sodium along with therapeutic dosages of indomethacin and ibuprofen. Our


Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs
The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs.
Piroxicam poisoning in a 2-year-old child. A case report.
This report describes the severe multisystem toxicity which followed ingestion of 5 piroxicam capsules (100 mg) by a 2-year-old child, resulting in severe fluid and electrolyte imbalance, mental confusion and a generalized seizure.
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  • 1980
Haemoperfusion seems to be the only therapeutic measure which is able to reduce the total body load of all pyrazolones to a toxicologically relevant extent.
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It is found that probenecid results in increased plasma concentrations of indomethacin with enhanced pain relief without increasing the incidence of side effects, and concomitant ingestion of food reduces and delays the peak concentrations without reducing the amount absorbed.
Acute Poisoning with Ibuprofen
The data suggest that ibuprofen is of low toxicity in acute overdose and that therapy used should be supportive only.
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    Clinical pharmacokinetics
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Since there is no correlation between the plasma level and the clinical or toxic effects of Phenylbutazone, there is at present no need for routine monitoring of plasma concentrations of the drug.
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Results indicate that, for a dose in the therapeutic range, a steady state was reached as early as the end of the 1st day of treatment and that tiaprofenic acid did not inhibit or induce its own biotransformation.
Do gastric contents modify antidotal efficacy of oral activated charcoal?
The effect of food on the antidotal efficacy of activated charcoal was studied in six healthy volunteers, who ingested aspirin 1000 mg, mexiletine 200 mg and tolfenamic acid 400 mg in a randomized
Non-steroidal analgesic and anti-inflammatory agents.
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  • Medicine
    British medical journal
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The circadian rhythms of human subjects without timepieces or indications of the alteration of day and night and the effects of "jet lag" on hormonal patterns are studied.
Mefenamic acid poisoning and epilepsy.
Results, like those reported recently by J H Shepherd and others, are not ideal and can be improved on by seeking the optimum dose regimen, as well as the best vehicle for release of PGE2 from the many available.