Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs

@article{Vale1986AcutePD,
  title={Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs},
  author={J Allister Vale and Ted Jordan Meredith},
  journal={Medical Toxicology},
  year={1986},
  volume={1},
  pages={12-31}
}
SummaryDespite the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), the current number of reported cases of poisoning is small However, with the introduction of ‘over-the-counter’ preparations of NSAIDs in some countries (e.g. ibuprofen in the UK and USA) an increased incidence of acute poisoning from this group of drugs can be expected. Conventionally, NSAIDs are divided into the following groups based on their chemical structure: arylpropionic acids, indole and indene acetic… Expand
13 – Minor analgesics and non-steroidal anti-inflammatory drugs
TLDR
Signs and symptoms of acute poisoning with NSAIDs include nausea, vomiting, headache, drowsiness, blurred vision, and dizziness, and treatment is largely supportive. Expand
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Most NSAID overdoses result in a benign outcome, but isolated case reports have documented serious toxicity, such as seizures, hypotension, apnoea, coma and renal failure. Expand
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TLDR
There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. Expand
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TLDR
Research relating to these adverse drug reactions, focusing on histopathological findings, which may contribute to the comprehension and possible avoidance of drug-induced disease is reviewed. Expand
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SummaryThe authors challenge the general view that the analgesic effect of the nonsteroidal anti-inflammatory drugs (NSAIDs) can be universally attributed to their inhibitory effects on the synthesisExpand
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TLDR
A case of perforated duodenal ulcer following acute overdose of ibuprofen in a patient with no other identified risk factors is described. Expand
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  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1990
TLDR
The article outlines the incidence, clinical toxicity, mode of action, and pharmacokinetics of nonsteroidal antiinflammatory drugs and general management recommendations for the treatment of NSAID toxicoses. Expand
Severe metabolic acidosis after acute naproxen sodium ingestion.
TLDR
The case of a 15-year-old girl who presented with severe metabolic acidosis and seizures that rapidly followed naproxen sodium ingestion is reported, and serum bicarbonate levels returned to normal 12 hours after admission and correlated with the known pharmacokinetics of Naproxen. Expand
Renal impairment after acute diclofenac, naproxen, and sulindac overdoses.
TLDR
Renal impairment after acute overdoses of nonsteroidal anti-inflammatory drugs was generally transient but in one case was treated by hemodialysis and one by continuous arterio-venous hemofiltration dialysis, and the risk of acute renal dysfunction must be considered. Expand
Dextropropoxyphene Overdose
TLDR
The importance of early diagnosis and treatment is stressed in view of the potentially lethal complications that may suddenly occur with this poisoning and caution is advised regarding the prescription for ‘at risk’ patients of alternative analgesics, which may be no safer in overdosage. Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs
TLDR
The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs. Expand
Piroxicam poisoning in a 2-year-old child. A case report.
TLDR
This report describes the severe multisystem toxicity which followed ingestion of 5 piroxicam capsules (100 mg) by a 2-year-old child, resulting in severe fluid and electrolyte imbalance, mental confusion and a generalized seizure. Expand
Intoxication with pyrazolones.
  • S. Okonek
  • Medicine
  • British journal of clinical pharmacology
  • 1980
TLDR
Haemoperfusion seems to be the only therapeutic measure which is able to reduce the total body load of all pyrazolones to a toxicologically relevant extent. Expand
Clinical Pharmacokinetics of Indomethacin
TLDR
It is found that probenecid results in increased plasma concentrations of indomethacin with enhanced pain relief without increasing the incidence of side effects, and concomitant ingestion of food reduces and delays the peak concentrations without reducing the amount absorbed. Expand
Acute Poisoning with Ibuprofen
TLDR
The data suggest that ibuprofen is of low toxicity in acute overdose and that therapy used should be supportive only. Expand
Clinical Pharmacokinetics of Phenylbutazone
  • J. Aarbakke
  • Chemistry, Medicine
  • Clinical pharmacokinetics
  • 1978
TLDR
Since there is no correlation between the plasma level and the clinical or toxic effects of Phenylbutazone, there is at present no need for routine monitoring of plasma concentrations of the drug. Expand
Pharmacokinetics of the anti-inflammatory tiaprofenic acid in humans, mice, rats, rabbits, and dogs.
TLDR
Results indicate that, for a dose in the therapeutic range, a steady state was reached as early as the end of the 1st day of treatment and that tiaprofenic acid did not inhibit or induce its own biotransformation. Expand
Do gastric contents modify antidotal efficacy of oral activated charcoal?
The effect of food on the antidotal efficacy of activated charcoal was studied in six healthy volunteers, who ingested aspirin 1000 mg, mexiletine 200 mg and tolfenamic acid 400 mg in a randomizedExpand
Non-steroidal analgesic and anti-inflammatory agents.
  • G. Nuki
  • Medicine
  • British medical journal
  • 1983
TLDR
The circadian rhythms of human subjects without timepieces or indications of the alteration of day and night and the effects of "jet lag" on hormonal patterns are studied. Expand
A case of poisoning with 10 grams of butazolidin.
  • T. Wramner
  • Medicine
  • Acta rheumatologica Scandinavica
  • 1956
TLDR
A 29-year-old man with ankylosing spondylitis who, after 6 weeks of successful treatment with Butazolidin, had duodenal ulcer and there was a relapse of ulcus and rapidly passing hemorrhages of the urinary tract. Expand
...
1
2
3
4
5
...