Acute Myeloid Leukemia.

@article{Dhner2015AcuteML,
  title={Acute Myeloid Leukemia.},
  author={Hartmut D{\"o}hner and Daniel J. Weisdorf and Clara Derber Bloomfield},
  journal={The New England journal of medicine},
  year={2015},
  volume={373 12},
  pages={
          1136-52
        }
}
AML is an aggressive cancer of the blood and bone marrow.1 AML prevents white blood cells from maturing, causing an accumulation of immature “blasts” (leukemic cells) which do not allow room for normal, healthy cells to grow.1 These leukemic cells can spread outside of the bloodstream and into other areas of the body, such as the central nervous system, skin and gums.1 As the leukemia spreads, infection, anemia or easy bleeding may occur due to a diminished number of healthy blood cells.1 In… Expand

Paper Mentions

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ConditionsAcute Myeloid Leukemia
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ConditionsAcute Myeloid Leukemia
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The Bone Marrow Niche - The Tumor Microenvironment That Ensures Leukemia Progression.
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  • Medicine, Biology
  • Advances in experimental medicine and biology
  • 2020
TLDR
The bone marrow microenvironment and its key importance for leukemia expansion are described and the several components of the bone marrow niche, their interaction with the leukemic cells and the cellular pathways activated within the malignant cells will be emphasized. Expand
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It is shown that CD123 is a good target for AML-directed CAR therapy, because its expression increases over time in vivo even in initially CD123(dim) populations, and that human CD123-redirected T cells (CART123) eradicate primary AML in immunodeficient mice. Expand
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
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