Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site

@article{Klingerman2015AcuteME,
  title={Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site},
  author={C. M. Klingerman and Michelle E. Stipanovic and A. Hajnal and C. Lynch},
  journal={Dose-Response},
  year={2015},
  volume={13}
}
  • C. M. Klingerman, Michelle E. Stipanovic, +1 author C. Lynch
  • Published 2015
  • Medicine
  • Dose-Response
  • Atypical antipsychotics (AAPs), such as olanzapine (OLZ), are associated with metabolic side effects, including hyperglycemia. Although a central mechanism of action for the acute effects on glycemia has been suggested, evidence for peripheral versus central effects of AAPs has been mixed and has not been explored for an effect of OLZ on the respiratory exchange ratio (RER). Here, we tested the hypothesis that some inconsistencies in the glycemic responses are likely a result of different doses… CONTINUE READING
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