Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site

  title={Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site},
  author={C. M. Klingerman and Michelle E. Stipanovic and A. Hajnal and C. Lynch},
  • C. M. Klingerman, Michelle E. Stipanovic, +1 author C. Lynch
  • Published 2015
  • Medicine
  • Dose-Response
  • Atypical antipsychotics (AAPs), such as olanzapine (OLZ), are associated with metabolic side effects, including hyperglycemia. Although a central mechanism of action for the acute effects on glycemia has been suggested, evidence for peripheral versus central effects of AAPs has been mixed and has not been explored for an effect of OLZ on the respiratory exchange ratio (RER). Here, we tested the hypothesis that some inconsistencies in the glycemic responses are likely a result of different doses… CONTINUE READING
    8 Citations
    AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis
    • 14
    • PDF
    Preclinical and Clinical Sex Differences in Antipsychotic-Induced Metabolic Disturbances: A Narrative Review of Adiposity and Glucose Metabolism
    • 9
    • Highly Influenced
    • PDF
    Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review
    • 7
    • PDF


    Intermittent treatment with olanzapine causes sensitization of the metabolic side-effects in rats
    • 43
    Insulin Resistance and Decreased Glucose-Stimulated Insulin Secretion After Acute Olanzapine Administration
    • 93
    Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.
    • 49
    • PDF
    Insulin resistance following continuous, chronic olanzapine treatment: An animal model
    • 56