Acute Lymphoblastic Leukemia in Children.
@article{Hunger2015AcuteLL, title={Acute Lymphoblastic Leukemia in Children.}, author={Stephen P. Hunger and Charles G. Mullighan}, journal={The New England journal of medicine}, year={2015}, volume={373 16}, pages={ 1541-52 } }
The most common cancer in childhood is now curable in 90% of patients. Current efforts are focused on devising molecular-based therapy for the subsets of acute lymphoblastic leukemia that are most resistant to current therapy.
1,116 Citations
Outcome of childhood acute lymphoblastic leukemia treatment in a single center in Brazil: A survival analysis study
- MedicineCancer reports
- 2021
There are few studies that demonstrate the results in Brazil and the probability of current overall survival (OS) is around 90% in developed countries.
Genomics in childhood acute myeloid leukemia comes of age
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A Children's Oncology Group study of nearly 1,000 pediatric acute myeloid leukemia (AML) cases reveals marked differences between the genomic landscapes of pediatric and adult AML and offers…
Outcomes of children and young adults with T‐cell acute lymphoblastic leukemia/lymphoma who present in critical status
- MedicinePediatric blood & cancer
- 2022
Patients with T‐cell acute lymphoblastic leukemia and lymphoma (T‐ALL/LLy) commonly present with critical features such as hyperleukocytosis and mediastinal mass, which complicates completing a…
Pediatric Acute Lymphoblastic Leukemia
- MedicineOncology
- 2019
Therapy options, including chimeric antigen receptor (CAR)-T-cell therapies for pediatric acute lymphoblastic leukemia (ALL), are discussed in ONCOLOGY.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah’s Witnesses patients: a feasible option in the age of hematopoietic growth factors
- MedicineLeukemia & lymphoma
- 2019
B-cell acute lymphoblastic leukemia (B-ALL) can be cured in most children and in the majority of young adults with sufficiently intensive – and myelosuppressive – combination chemotherapy regimens ...
CAR-T Cells: An Innovative Therapeutic Strategy Against Pediatric Acute Lymphoblastic Leukemia
- Medicine, BiologyResearch in Molecular Medicine (RMM)
- 2019
Acute lymphoblastic leukemia (ALL) is a prevalent and highly progressive cancer in children and adolescents associated with an excessive production of immature lymphocytes in the bone marrow, which…
Immunotherapy in Pediatric Acute Lymphoblastic Leukemia
- MedicineJournal of Cancer Immunology
- 2020
Treatment for patients with B-ALL remains a therapeutic challenge despite successes due to multi-agent chemotherapy regiments, CNS prophylaxis and better risk stratification.
Pediatric patients with acute lymphoblastic leukemia treated with blinatumomab in a real‐world setting: Results from the NEUF study
- MedicinePediatric blood & cancer
- 2022
Prior to regulatory approval of blinatumomab in pediatric patients with relapsed/refractory Philadelphia chromosome‐negative B‐cell precursor acute lymphoblastic leukemia (R/R Ph− BCP‐ALL),…
L‐asparaginase doses number as a prognostic factor in childhood acute lymphoblastic leukemia: A survival analysis study
- MedicineCancer reports
- 2021
The survival of children with acute lymphoblastic leukemia (ALL) has improved due to changes in the treatment and the disease diagnosis. A significant advance was the incorporation of asparaginase.…
Thrombotic potential during pediatric acute lymphoblastic leukemia induction: Role of cell‐free DNA
- Medicine, BiologyResearch and practice in thrombosis and haemostasis
- 2021
Thromboembolism affects up to 30% of children undergoing treatment for acute lymphoblastic leukemia (ALL). Increased thrombin generation has been reported in ALL, but the mechanisms remain elusive.
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