Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

@article{Centa2018AcuteLO,
  title={Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.},
  author={Monica Centa and Kajsa E Prokopec and Manasa G. Garimella and Katrin Habir and Lisa Hofste and Julian M Stark and Albert Dahdah and Chris A Tibbitt and Konstantinos Polyzos and Anton Gister{\aa} and Daniel Klingberg Johansson and Nobuyo N Maeda and G{\"o}ran K. Hansson and Daniel F.J. Ketelhuth and Jonathan M Coquet and Christoph J. Binder and Mikael C I Karlsson and Stephen Malin},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2018},
  volume={38 8},
  pages={
          e145-e158
        }
}
Objective- Dyslipidemia is a component of the metabolic syndrome, an established risk factor for atherosclerotic cardiovascular disease, and is also observed in various autoimmune and chronic inflammatory conditions. However, there are limited opportunities to study the impact of acquired dyslipidemia on cardiovascular and immune pathology. Approach and Results- We designed a model system that allows for the conversion to a state of acute hyperlipidemia in adult life, so that the consequences… CONTINUE READING
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