Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.

  title={Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.},
  author={Stephen J Bailey and Paul G. Winyard and Anni Vanhatalo and Jamie R. Blackwell and Fred J. DiMenna and Daryl P. Wilkerson and Andrew M. Jones},
  journal={Journal of applied physiology},
  volume={109 5},
It has recently been reported that dietary nitrate (NO(3)(-)) supplementation, which increases plasma nitrite (NO(2)(-)) concentration, a biomarker of nitric oxide (NO) availability, improves exercise efficiency and exercise tolerance in healthy humans. We hypothesized that dietary supplementation with L-arginine, the substrate for NO synthase (NOS), would elicit similar responses. In a double-blind, crossover study, nine healthy men (aged 19-38 yr) consumed 500 ml of a beverage containing 6 g… 

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Acute l-arginine supplementation increases muscle blood volume but not strength performance.

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Acute Effects of L-Arginine Supplementation on Oxygen Consumption Kinetics and Muscle Oxyhemoglobin and Deoxyhemoglobin during Treadmill Running in Male Adults

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Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

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Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

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L-arginine reduces exercise-induced increase in plasma lactate and ammonia.

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L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production.

It is concluded that administration of L-arginine restores exercise-induced EDNO synthesis and normalizes aerobic capacity in hypercholesterolemic mice.

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