Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.

@article{Bailey2010AcuteLS,
  title={Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.},
  author={Stephen J Bailey and Paul G. Winyard and Anni Vanhatalo and Jamie R. Blackwell and Fred J. DiMenna and Daryl P. Wilkerson and Andrew M. Jones},
  journal={Journal of applied physiology},
  year={2010},
  volume={109 5},
  pages={
          1394-403
        }
}
It has recently been reported that dietary nitrate (NO(3)(-)) supplementation, which increases plasma nitrite (NO(2)(-)) concentration, a biomarker of nitric oxide (NO) availability, improves exercise efficiency and exercise tolerance in healthy humans. We hypothesized that dietary supplementation with L-arginine, the substrate for NO synthase (NOS), would elicit similar responses. In a double-blind, crossover study, nine healthy men (aged 19-38 yr) consumed 500 ml of a beverage containing 6 g… 

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...

References

SHOWING 1-10 OF 81 REFERENCES

Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

The reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production.

L-arginine reduces exercise-induced increase in plasma lactate and ammonia.

Results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia, and might support that L- ARG supplementation enhances the L-arginine-nitric oxide (NO) pathway during exercise.

L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production.

It is concluded that administration of L-arginine restores exercise-induced EDNO synthesis and normalizes aerobic capacity in hypercholesterolemic mice.

Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exercise.

Exogenous L-arginine administration speeds the phase II pulmonary VO2 response by 12% at the onset of moderate-intensity exercise in humans.

Nitric oxide and iron metabolism in exercised rat with L-arginine supplementation

The results showed that Arg supplementation in exercise (EAG) significantly increased nitrite and nitrate (NOx) concentration in the kidney and BMC, rather than in the liver, spleen and heart, which suggest that Arg supplements in exercise, possibly through increasing NO synthesis, may change CI formation in the kidneys and BMC.

Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension.

Oral supplementation of L-arginine significantly increased plasma L-citrulline, which indicated enhancement of NO production and suggested beneficial effects on hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension.

Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise.

The speeding of the primary component Vo(2) kinetics after L-NAME infusion indicates that at least part of the intrinsic inertia to oxidative metabolism at the onset of heavy-intensity exercise may result from inhibition of mitochondrial Vo( 2) by nitric oxide.
...