• Psychology, Medicine
• Published in Neuropsychopharmacology 2008
• DOI:10.1038/sj.npp.1301535

Acute Injections of the NMDA Receptor Antagonist Memantine Rescue Performance Deficits of the Ts65Dn Mouse Model of Down Syndrome on a Fear Conditioning Test

@article{Costa2008AcuteIO,
  title={Acute Injections of the NMDA Receptor Antagonist Memantine Rescue Performance Deficits of the Ts65Dn Mouse Model of Down Syndrome on a Fear Conditioning Test},
  author={Alberto C S Costa and Jonah J Scott-McKean and Melissa R. Stasko},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1624-1632}
}

• Alberto C S Costa, Jonah J Scott-McKean, Melissa R. Stasko

Individuals with Down syndrome (DS) and Ts65Dn mice (a major animal model of DS) carry an extra copy of the DSCR1 (Down Syndrome Critical Region 1) gene, which encodes for a protein that inhibits calcineurin. Calcineurin itself has been shown to modulate N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation kinetics by decreasing channel mean open time and opening probability. We hypothesize that the overexpression of DSCR1 in persons with DS and Ts65Dn mice would inhibit normal calcineurin… CONTINUE READING

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