Acute Injections of the NMDA Receptor Antagonist Memantine Rescue Performance Deficits of the Ts65Dn Mouse Model of Down Syndrome on a Fear Conditioning Test

@article{Costa2008AcuteIO,
  title={Acute Injections of the NMDA Receptor Antagonist Memantine Rescue Performance Deficits of the Ts65Dn Mouse Model of Down Syndrome on a Fear Conditioning Test},
  author={Alberto C S Costa and Jonah J Scott-McKean and Melissa R. Stasko},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1624-1632}
}
Individuals with Down syndrome (DS) and Ts65Dn mice (a major animal model of DS) carry an extra copy of the DSCR1 (Down Syndrome Critical Region 1) gene, which encodes for a protein that inhibits calcineurin. Calcineurin itself has been shown to modulate N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation kinetics by decreasing channel mean open time and opening probability. We hypothesize that the overexpression of DSCR1 in persons with DS and Ts65Dn mice would inhibit normal calcineurin… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 88 CITATIONS, ESTIMATED 70% COVERAGE

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

  • Genes, brain, and behavior
  • 2008
VIEW 14 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS

Glutamatergic synapses in neurodevelopmental disorders

  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Rodent models in Down syndrome research: impact and future opportunities

  • Disease models & mechanisms
  • 2017
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

  • Drug design, development and therapy
  • 2014
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Predicting pathway perturbations in Down syndrome.

  • Journal of neural transmission. Supplementum
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Low doses of memantine disrupt memory in adult rats.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 2 EXCERPTS