Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus: The ADVANCE Trial

  title={Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus: The ADVANCE Trial},
  author={Toshiaki Ohkuma and Min Jun and Anthony Rodgers and Mark Emmanuel Cooper and Paul P. Glasziou and Pavel Hamet and Stephen B Harrap and Giuseppe Mancia and Michel Marre and Bruce Neal and Vlado Perkovic and Neil R. Poulter and Bryan Williams and Sophia Zoungas and John Chalmers and Mark Woodward},
Discontinuation of angiotensin-converting enzyme (ACE) inhibitor is recommended if patients experience ≥30% acute increase in serum creatinine after starting this therapy. However, the long-term effects of its continuation or discontinuation on major clinical outcomes after increases in serum creatinine are unclear. In the ADVANCE trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation), 11 140 diabetes mellitus patients were randomly… 

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