Acute Hemodynamic Effects of Tolvaptan , a Vasopressin V 2 Receptor Blocker , in Patients With Symptomatic Heart Failure and Systolic Dysfunction An International , Multicenter , Randomized , Placebo-Controlled Trial

@inproceedings{Udelson2008AcuteHE,
  title={Acute Hemodynamic Effects of Tolvaptan , a Vasopressin V 2 Receptor Blocker , in Patients With Symptomatic Heart Failure and Systolic Dysfunction An International , Multicenter , Randomized , Placebo-Controlled Trial},
  author={James E. Udelson and Cesare Orlandi and John Ronghua Ouyang and Holly B. Krasa and Christopher A. Zimmer and Geir P Frivold and W. Herbert Haught and Sheiba Meymandi and Cezar Macarie and Dimitar Raef and Patricia Wedge and Marvin A. Konstam and Mihai Gheorghiade},
  year={2008}
}
Results Tolvaptan at all doses significantly reduced pulmonary capillary wedge pressure ( 6.4 4.1 mm Hg, 5.7 4.6 mm Hg, 5.7 4.3 mm Hg, and 4.2 4.6 mm Hg for the 15-mg, 30-mg, 60-mg, and placebo groups, respectively; p 0.05 for all tolvaptan vs. placebo). Tolvaptan also reduced right atrial pressure ( 4.4 6.9 mm Hg [p 0.05], 4.3 4.0 mm Hg [p 0.05], 3.5 3.6 mm Hg, and 3.0 3.0 mm Hg for the 15-mg, 30-mg, 60-mg, and placebo groups, respectively) and pulmonary artery pressure ( 5.6 4.2 mm Hg, 5.5 4… CONTINUE READING
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