Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report.

@article{Nakano2017AcuteGR,
  title={Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report.},
  author={Ryosuke Nakano and Masahiro Ohira and Kohei Ishiyama and Kentaro Ide and Tsuyoshi Kobayashi and Hiroyuki Tahara and Seiichi Shimizu and K. Arihiro and Michio Imamura and Kazuaki Chayama and Yuka Tanaka and Hideki Ohdan},
  journal={Transplantation proceedings},
  year={2017},
  volume={49 7},
  pages={1634-1638}
}
BACKGROUND We report a case of acute rejection of a liver graft, together with the occurrence of de novo donor-specific antibodies (DSAs), in a 53-year-old Japanese man who had undergone deceased-donor liver transplantation. METHODS The graft rejection was triggered by low cyclosporine levels and pegylated interferon treatment for the recurrence of hepatitis C virus (HCV) infection 18 months after transplantation. Although the graft was ABO-compatible, pre-formed DSA B51 was detected… CONTINUE READING