Acute Glucagon Induces Postprandial Peripheral Insulin Resistance

@inproceedings{Patarro2015AcuteGI,
  title={Acute Glucagon Induces Postprandial Peripheral Insulin Resistance},
  author={Rita S. Patarr{\~a}o and W. Wayne Lautt and M Paula Macedo},
  booktitle={PloS one},
  year={2015}
}
Glucagon levels are often moderately elevated in diabetes. It is known that glucagon leads to a decrease in hepatic glutathione (GSH) synthesis that in turn is associated with decreased postprandial insulin sensitivity. Given that cAMP pathway controls GSH levels we tested whether insulin sensitivity decreases after intraportal (ipv) administration of a cAMP analog (DBcAMP), and investigated whether glucagon promotes insulin resistance through decreasing hepatic GSH levels.Insulin sensitivity… CONTINUE READING
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