Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)

@article{Gaur2017AcuteGS,
  title={Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)},
  author={M. Gaur and L. Wang and Alex and ra Amaro-Ortiz and M. Dobke and I. K. Jordan and V. Lunyak},
  journal={Journal of Stem Cell Research & Therapy},
  year={2017},
  volume={7},
  pages={1-13}
}
MSC mediate numerous therapeutic effects by promoting repair directly via differentiation into critical cell types or indirectly through the secretion of a broad spectrum of soluble factors with diverse paracrine activities. However, recent discoveries indicate that MSC are sensitive to endogenous and exogenous stressors and many diseaserelated interventions can result in Therapy-Induced Senescence (TIS) in MSC. Here, we provide a detailed analysis of changes in secretory factors that occur… Expand
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