Acute Flaccid Paralysis and Enteroviral Infections

@article{Bitnun2018AcuteFP,
  title={Acute Flaccid Paralysis and Enteroviral Infections},
  author={Ari Bitnun and E. Ann Yeh},
  journal={Current Infectious Disease Reports},
  year={2018},
  volume={20},
  pages={1-15}
}
Purpose of ReviewThe focus of this review is on enterovirus (EV)-associated acute flaccid paralysis (AFP) due to spinal cord anterior horn cell disease. Emphasis is placed on the epidemiology, pathogenesis, diagnosis, treatment, and outcome of AFP caused by polioviruses, vaccine-derived polioviruses, EV-D68, and EV-A71.Recent FindingsSince the launch of The Global Polio Eradication Initiative in 1988, the worldwide incidence of polio has been reduced by 99.9%, with small numbers of… Expand
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References

SHOWING 1-10 OF 144 REFERENCES
Enterovirus 71 infection and vaccines
TLDR
Developing vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks and to protect against fatal complications of HFMD, focusing on current scientific and clinical progress. Expand
Clinical features, diagnosis, and management of enterovirus 71
TLDR
Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis, and intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Expand
Poliomyelitis-like illness due to Japanese encephalitis virus
TLDR
Compared with Jev-negative patients, weakness in JEV-infected children was more rapid in onset, tended to be asymmetrical, but was less likely to involve the arms, and nerve conduction and electromyographic studies indicated damage to the anterior horn cells. Expand
Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge.
TLDR
EV71 infection should be considered in young children presenting with aseptic meningitis, encephalitis, acute flaccid paralysis, or acute cardiopulmonary collapse, and likely remains unrecognized in other parts of the United States, because EV-PCR of cerebrospinal fluid frequently yields negative results. Expand
Enterovirus type 71 infections: a varied clinical pattern sometimes mimicking paralytic poliomyelitis.
  • J. Melnick
  • Medicine
  • Reviews of infectious diseases
  • 1984
TLDR
Among the most recently recognized agents able to cause severe central nervous system disease with persistent flaccid paralysis is enterovirus type 71, which is also significant in relation to polio vaccines. Expand
Enterovirus and Human Parechovirus Surveillance - United States, 2009-2013.
TLDR
Clinicians and public health practitioners should consider the EV and HPeV types recently circulating in the United States to inform diagnostic and surveillance activities and report their results to improve the reliability and generalizability of surveillance data. Expand
Enterovirus d68. A focused review and clinical highlights from the 2014 U.S. Outbreak.
TLDR
A focused review of EV-D68 respiratory disease and clinical highlights from the 2014 U.S. outbreak are presented here. Expand
Enteroviruses in the early 21st century: new manifestations and challenges
TLDR
Clinicians should be aware of the respiratory and neurological manifestations associated with EV-D68 and the potential for severe disease seen with other recently described enterovirus variants, and healthcare professionals should recognize the utility of rapid diagnostic methods and progress toward prevention and treatment of enterov virus infections. Expand
Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
TLDR
This study demonstrates the extensive diversity and diverse circulation patterns of NPEVs from AFP surveillance and highlights the need to formulate effective long-term strategies to monitor NPEV circulations in West Africa. Expand
West Nile Virus–associated Flaccid Paralysis
TLDR
A poliomyelitislike syndrome likely involving spinal anterior horn cells is the most common mechanism of WNV-associated paralysis and is associated with significant short- and long-term illness and death. Expand
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